• Kia Teng Lim, Kia Hui Lim, Xuan Zhou, Juan Yang, Kyung-Min Shin, Arya B Mohabbat, Wyatt W Baude, Sanjeev Nanda, David Bauer, Monique Theberath, Nicole Theberath, Brent A Bauer, and Ravindra Ganesh.
• Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
• Am. J. Chin. Med. 2022 Jan 1; 50 (5): 1197-1218.

AbstractPain is the most frequently encountered symptom by patients with fibromyalgia (FM). Dietary supplements (DSs) in particular have a proven impact as a possible adjunctive therapy for symptom management in FM. However, there is currently no conclusive review outlining the evidence for DSs in pain management in FM. This study aims to assess currently available studies evaluating the use of DSs for pain relief in FM. Randomized controlled trials regarding the use of DSs on adult FM patients were included for evidence synthesis. Study results indicated that DSs significantly relieved pain in FM (SMD 1.23; 95% CI 0.02-2.43, P = 0.046) but did not improve quality of life (QoL) (SMD 0.73; 95% CI -0.07-1.53, P = 0.075) in the data. Adverse events of DSs varied from mild to severe, with the most common being gastrointestinal symptoms and androgenic side effects in 5.7% and 3.9% of patients, respectively. More well-designed RCTs are required in the future. The protocol for this review has been published on PROSPERO (CRD42020149941).

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