• Internal medicine · Jan 2023

    Case Reports

    A Case of Muscle Biopsy-proven Drug-induced Microscopic Polyangiitis in a Patient with Tuberculosis.

    • Gaku Kuwabara, Koichi Yamada, Kiyomi Tanaka, Satoshi Nozuchi, Waki Imoto, Wataru Shibata, Mitsunori Tohda, Shigenori Kyoh, Yoshiaki Itoh, Motomu Hashimoto, and Hiroshi Kakeya.
    • Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan.
    • Intern. Med. 2023 Jan 1; 62 (1): 129133129-133.

    AbstractWe herein report a case of muscle biopsy-proven microscopic polyangiitis (MPA) in a patient with tuberculosis. The patient had developed a persistent fever after the initiation of treatment for tuberculosis and was positive for myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA). However, because conventional symptoms were lacking, determination of the biopsy site was difficult. Based on the findings of a biopsy of the biceps femoris, which confirmed small vessel vasculitis, the patient was diagnosed with MPA. The fever was alleviated by glucocorticoids. Tuberculosis and antituberculosis drugs can cause ANCA-associated vasculitis (AAV). A muscle biopsy is useful for the diagnosis of AAV.

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