• J Eval Clin Pract · Oct 2022

    Precision medicine and diseases as natural kinds: An epistemological dilemma.

    • Ahti-Veikko Pietarinen and Donald E Stanley.
    • Ragnar Nurkse Department of Innovation and Governance, Tallinn University of Technology, Tallinn, Estonia.
    • J Eval Clin Pract. 2022 Oct 1; 28 (5): 835842835-842.

    BackgroundThe most important advance of precision medicine (PM) has been a specific way to define and understand disease. However, PM may fail to be therapeutically effective if diseases are natural kinds.ObjectiveTo attest adverse consequences of treatments suggested by PM that do not generalize well.MethodsConceptual analysis of PM; Epistemology of clinical reasoning; Cases that show diseases as natural kinds to clash with epistemology of PM.ResultsContemplation of future research options that could clarify the position of PM under the conception of diseases as natural kinds.ConclusionNeed for improved design of future interventions that better acknowledge problematic epistemology of PM.© 2022 John Wiley & Sons Ltd.

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