• J. Am. Vet. Med. Assoc. · Nov 2012

    Randomized Controlled Trial

    Evaluation of a ketamine-propofol drug combination with or without dexmedetomidine for intravenous anesthesia in cats undergoing ovariectomy.

    • Giuliano Ravasio, Martina Gallo, Michela Beccaglia, Stefano Comazzi, Maria Elena Gelain, Diego Fonda, Valerio Bronzo, and Annalisa Zonca.
    • Department of Veterinary Sciences and Public Health, Università degli Studi di Milano, 20133 Milan, Italy.
    • J. Am. Vet. Med. Assoc. 2012 Nov 15;241(10):1307-13.

    ObjectiveTo evaluate the use of a ketamine-propofol combination, with or without dexmedetomidine, in cats undergoing ovariectomy and to assess Heinz body formation following administration of these drugs.DesignRandomized clinical trial.Animals15 client-owned female cats.ProceduresAnesthesia was induced with a ketamine (2.0 mg/kg [0.91 mg/lb])-propofol (2.0 mg/kg) combination with (n = 7) or without (8) dexmedetomidine (0.003 mg/kg [0.0013 mg/lb]) and was maintained via continuous IV infusion of a 1:1 ketamine-propofol combination (administration rate for each drug, 10.0 mg/kg/h [4.54 mg/lb/h]). Cats underwent ovariectomy; duration of infusion was 25 minutes. Physiologic variables were measured at predetermined time points. Heinz bodies were quantified via examination of blood smears. Numeric scales were used to assess quality of recovery, degree of sedation, and signs of pain after surgery.ResultsThe ketamine-propofol group had a significantly higher mean heart rate at several time points during drug infusion, a significantly shorter time from the end of infusion to extubation (7 vs 29 minutes), and significantly lower sedation scores for the first hour after surgery than did the ketamine-propofol-dexmedetomidine group. Other variables were similar between groups; recovery was smooth, and anesthesia and postoperative analgesia were deemed adequate for all cats. The number of RBCs with Heinz bodies was not increased after surgery, compared with values immediately after anesthetic induction.Conclusions And Clinical RelevanceTotal IV anesthesia with a ketamine-propofol combination, with or without dexmedetomidine, appeared to be effective in healthy cats. These short-term infusions produced smooth recovery and adequate analgesia during the postoperative period.

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