• World Neurosurg · Sep 2022

    Peripheral Monocyte percentage as a potential indicator of prognosis in patients with chronic subdural hematoma receiving conservative therapy.

    • Dong Wang, Yueshan Fan, Yibing Fan, Zengguang Wang, Liang Yang, Jinhao Huang, Chuang Gao, Zilong Zhao, Jianning Zhang, and Rongcai Jiang.
    • Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
    • World Neurosurg. 2022 Sep 1; 165: e92e101e92-e101.

    BackgroundStudies have confirmed active and abnormal inflammation in the hematoma cavity of chronic subdural hematoma (CSDH). However, a relationship between the peripheral blood status and the prognosis of CSDH patients has not been demonstrated.MethodsWe retrospectively analyzed 245 CSDH patients who received conservative therapy (67 under close follow-up observation, 103 treated with atorvastatin, and 75 treated with atorvastatin combined with dexamethasone) from 2014 to 2021 to evaluate the role of major inflammation-associated cells in the prognostic assessment of patients. Univariate and multivariate analyses were performed to assess the potential factors that could indicate the prognosis among the 103 patients who underwent observation only or atorvastatin therapy. Changes in peripheral blood inflammation-associated cells at different time points were compared between patients with good and poor outcomes. Furthermore, the changes in inflammatory cells in 75 patients who received atorvastatin combined with dexamethasone were analyzed.ResultsThe monocyte percentage was the only independent influencing factor in subsequent follow-up assessments. Patients with good outcomes had obviously lower circulating monocyte percentages in their peripheral blood counts throughout the treatment period. The monocyte percentage was also significantly decreased in the patients who responded well to atorvastatin combined with dexamethasone. The peripheral monocyte percentage was significantly higher in patients who transitioned to surgery because of a poor response to pharmacotherapy.ConclusionsThe peripheral monocyte percentage may be a convenient and effective indicator for predicting the outcome of CSDH for patients receiving conservative treatment. A higher percentage of monocytes could be a risk factor for a poor response.Copyright © 2022 Elsevier Inc. All rights reserved.

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