• Joshua M Diamond, M Beatriz Lopes, W Jeff Elias, and Laura A Jansen.
• Department of Neurological Surgery, University of Virginia Medical Center, Charlottesville, Virginia, USA.
• World Neurosurg. 2022 Sep 1; 165: e159e168e159-e168.

BackgroundThe gamma-aminobutyric acid A (GABAA) receptor is an important mediator of cellular signaling in the globus pallidus and might be implicated in the pathophysiology of Parkinson disease (PD). The goal of the present study was to characterize GABAA receptor subunit expression in the normal and parkinsonian human globus pallidus.MethodsPostmortem brain specimens were obtained from 8 patients with pathological evidence of PD at autopsy and from 4 control patients without such evidence. These tissues were exposed to primary antibodies directed against the α1 and α3 subunits of the GABAA receptor and were visualized and quantified using fluorescence microscopy.ResultsNo differences were found in the pallidal neuronal density in the control versus PD tissues. Projection neurons strongly expressed the α1, α3, and β2 GABAA receptor subunits. After normalizing the immunofluorescence intensities in the globus pallidus to those in the adjacent structures, no significant differences were found in GABAA receptor subunit expression in the globus pallidus between the PD specimens and the control specimens.ConclusionsCompensatory changes in GABAA receptor α1 and α3 subunit expression in response to PD-related signaling abnormalities in the globus pallidus did not occur in our PD cohort.Copyright © 2022 Elsevier Inc. All rights reserved.

16 keywords...

hide…