• Sukwoo Hong, Kenji Kagawa, Kengo Sato, Ryutaro Nomura, and Shunsuke Ichi.
• Department of Neurosurgery, Japanese Red Cross Medical Center, Tokyo, Japan. Electronic address: honsohkaisei6031@gmail.com.
• World Neurosurg. 2022 Aug 1; 164: e1200-e1208.

BackgroundData on the outcomes of CyberKnife-based hypofractionated stereotactic radiosurgery (hSRS) for intracranial and extracranial nonvestibular schwannomas (nVSs) are not sufficient.MethodsPatients who underwent hSRS for nVSs between 2010 and 2019 were retrospectively reviewed.ResultsA total of 39 patients with 39 nVSs were identified. The mean age was 53 (±18) years, and 20 patients (51%) were women. Twenty-five patients (64%) had previous surgeries. Seventeen patients (44%) had nVSs extending outside the cranium. The mean prescribed dose covering 95% of the planning target volume was 22 Gy (±3.7 Gy), the mean fractionation was 4 (±2), and the mean target volume was 13 cm3 (±16 cm3). The radiological tumor control rate was 100% during the mean follow-up period of 67 months (±37 months). Thirty-seven patients (95%) were clinically stable during the mean follow-up period of 72 months (±35 months). Nine patients (23%) suffered from transient adverse radiation effects (AREs), including transient tumor expansion, and 2 (5%) suffered from permanent AREs.ConclusionsWe summarized the treatment outcomes of hSRS for nVSs. Although all patients achieved radiological tumor control, the risk of either transient or permanent ARE was high. Therefore, it is necessary to monitor patients for clinical deterioration due to AREs.Copyright © 2022 Elsevier Inc. All rights reserved.

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