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Critical care clinics · Jul 2022
ReviewCOVID-19 Acute Respiratory Distress Syndrome: One Pathogen, Multiple Phenotypes.
- Susannah Empson, Angela J Rogers, and Jennifer G Wilson.
- Department of Anesthesiology, Perioperative, and Pain Medicine, 300 Pasteur Drive, H3580, Stanford, CA 94305, USA. Electronic address: sfempson@stanford.edu.
- Crit Care Clin. 2022 Jul 1; 38 (3): 505519505-519.
AbstractAcute respiratory distress syndrome (ARDS) is a heterogeneous syndrome arising from multiple causes with a range of clinical severity. In recent years, the potential for prognostic and predictive enrichment of clinical trials has been increased with identification of more biologically homogeneous subgroups or phenotypes within ARDS. COVID-19 ARDS also exhibits significant clinical heterogeneity despite a single causative agent. In this review the authors summarize the existing literature on COVID-19 ARDS phenotypes, including physiologic, clinical, and biological subgroups as well as the implications for improving both prognostication and precision therapy.Copyright © 2022 Elsevier Inc. All rights reserved.
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