• Critical care clinics · Jul 2022

    Review

    Severe COVID-19 and Multisystem Inflammatory Syndrome in Children in Children and Adolescents.

    • Allison M Blatz and Adrienne G Randolph.
    • Department of Pediatrics, Division of Infectious Diseases, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
    • Crit Care Clin. 2022 Jul 1; 38 (3): 571586571-586.

    AbstractSevere complications related to COVID-19 occur infrequently in children and adolescents. these life-threatening complications are mainly acute respiratory failure from acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C). MIS-C is a postinfectious complication occurring approximately 3 to 6 weeks mostly after an asymptomatic or mild SARS-CoV-2 infection. For both types of complications, supportive ICU care is often required. For MIS-C critical illness, immunomodulation is prescribed to reverse hyperinflammation and its cardiac and other sequelae.Copyright © 2022 Elsevier Inc. All rights reserved.

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