• Amnah Alamer, Syed Mohammed Basheeruddin Asdaq, Mohammad AlYamani, Hussain AlGhadeer, Zahra H Alnasser, Zainab Aljassim, Maryam Albattat, Ahmed Alhajji, Ahmed Alrashed, Yahya Mozari, Abrar Aledrees, Badr Almuhainy, Ivo Abraham, and Ahmad Alamer.
• From the Department of Internal Medicine, King Faisal University, Al Hasa, Saudi Arabia.
• Ann Saudi Med. 2022 May 1; 42 (3): 165-173.

BackgroundAbout 5-10% of coronavirus disease 2019 (COVID-19) infected patients require critical care hospitalization and a variety of respiratory support, including invasive mechanical ventilation. Several nationwide studies from Saudi Arabia have identified common comorbidities but none were focused on mechanically ventilated patients in the Al-Ahsa region of Saudi Arabia.ObjectivesIdentify characteristics and risk factors for mortality in mechanically ventilated COVID-19 patients.DesignRetrospective chart review SETTING: Two general hospitals in the Al-Ahsa region of Saudi Arabia PATIENTS AND METHODS: We included mechanically ventilated COVID-19 patients (>18 years old) admitted between 1 May and 30 November 2020, in two major general hospitals in the Al-Ahsa region, Saudi Arabia. Descriptive statistics were used to characterize patients. A multivariable Cox proportional hazards (CPH) model was used exploratively to identify hazard ratios (HR) of predictors of mortality.Main Outcome MeasuresPatient characteristics, mortality rate, extubation rate, the need for re-intubation and clinical complications during hospitalization.Sample Size And Characteristics154 mechanically ventilated COVID-19 patients with median (interquartile range) age of 60 (22) years; 65.6% male.ResultsCommon comorbidities were diabetes (72.2%), hypertension (67%), cardiovascular disease (14.9%) and chronic kidney disease (CKD) (14.3%). In the multivariable CPH model, age >60 years old (HR=1.83, 95% CI 1.2-2.7, P=.002), CKD (1.61, 95% CI 0.9-2.6, P=.062), insulin use (HR=0.65, 95% CI 0.35-.08, P<.001), and use of loop diuretics (HR=0.51, 95% CI 0.4, P=.037) were major predictors of mortality.ConclusionCommon diseases in mechanically ventilated COVID-19 patients from the Al-Ahsa region were diabetes, hypertension, other cardiovascular diseases, and CKD in this exploratory analysis.LimitationsRetrospective, weak CPH model performance.Conflicts Of InterestNone.

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