• Ir J Med Sci · Apr 2023

    Serum Elabela level is significantly increased in patients with acromegaly.

    • Hilmi Erdem Sumbul, Erdinc Gulumsek, Begum Seyda Avci, Nurettin Ay, Ramazan Azim Okyay, Ahmet Riza Sahin, Jeffrey Gold, Akkan Avci, and Mevlut Koc.
    • Department of Internal Medicine, Health Science University, Adana City Research and Training Hospital, Adana, Turkey.
    • Ir J Med Sci. 2023 Apr 1; 192 (2): 665670665-670.

    BackgroundAlthough the bioactive peptides associated with the apelinergic system are known to be associated with heart failure and ischemic heart disease, there are no data on their association with acromegaly.AimWe aimed to investigate the change in serum Elabela levels, a novel peptide of the apelinergic system, in patients with acromegaly.MethodsOur study included 30 treatment naive patients who were recently diagnosed with acromegaly, and 50 age-and-sex-matched healthy controls. In addition to routine history, physical examination and laboratory examinations, serum Elabela level was measured. Participants were divided into two groups as individuals with and without acromegaly and compared to each other.ResultsDiastolic blood pressure (DBP) and systolic blood pressure (SBP) were found to be higher in patients with acromegaly. Serum glucose, Hs-CRP, NT-proBNP, insulin-like growth factor-1, growth hormone and serum Elabela levels were higher in patients with acromegaly (p < 0.05 for each). Left ventricular ejection fraction (LV-EF) was found to be lower in patients with acromegaly than the patients in healthy control group (p < 0.05). In multivariate analysis; age, systolic blood pressure, NT-proBNP, Insulin-like growth factor 1 and growth hormone levels were found to be very closely and positively related to serum Elabela level (p < 0.05 for each).ConclusionsSerum Elabela level can be used as an early and objective indicator of early cardiovascular involvement in patients with acromegaly. Further research is needed to clarify the role of serum Elabela levels on cardiovascular system in acromegaly patients.© 2022. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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