• Best Pract Res Clin Anaesthesiol · Dec 2004

    Review

    Renal protection strategies in the perioperative period.

    • Per-Olof Jarnberg.
    • Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA. jarnberg@ohsu.edu
    • Best Pract Res Clin Anaesthesiol. 2004 Dec 1; 18 (4): 645-60.

    AbstractThe development of acute renal failure (ARF) in the perioperative period continues to be a vexing condition associated with high morbidity and mortality rates which have been unchanged for several decades. In this article I briefly review recent research categorizing pathogenesis of ARF and mechanisms of recovery. Once ARF is established, its maintenance phase is dependent on several mechanisms that interact with cellular integrity. The main focus of the article is on assessing clinical and experimental interventions to prevent ARF. Unfortunately, existing pharmacological and other interventions show a rather limited efficacy in preventing ARF.

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