• Medicina clinica · Sep 2022

    Review

    Autoimmune hepatitis: Challenges and novelties.

    • Ignasi Olivas, Sergio Rodríguez-Tajes, and Maria Carlota Londoño.
    • Servicio de Hepatología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, España.
    • Med Clin (Barc). 2022 Sep 23; 159 (6): 289-298.

    AbstractAutoimmune hepatitis is a chronic inflammatory disease of the liver. The etiology is partly unknown and commonly affects women of all ages. It is characterized by increase in transaminase and immunoglobulin G levels, autoantibodies, and portal inflammatory infiltrate with interface hepatitis in the liver biopsy. The treatment is based on the combination of corticoids and azathioprine, but 20-40% of patients require second- or third-line therapies due to intolerance or insufficient response. Here, we will revise the most important aspects regarding the diagnosis and treatment of autoimmune hepatitis emphasizing the challenges faced in clinical practice.Copyright © 2022 Elsevier España, S.L.U. All rights reserved.

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