• Ushab Rana Mohsin, Nabin Simkhada, Deep PathakBishnuBShree Birendra Hospital, Chhauni, Kathmandu, Nepal., Bishal Dhakal, Binaya Subedi, Dilip Thapa, Bishnu Prasad Shrestha, Om Prakash Tandon, Sanjaya Shrestha, Shriya Sharma, and Aakriti Adhikari.
• Department of Pulmonology, Shree Birendra Hospital, Chhauni, Kathmandu, Nepal.
• JNMA J Nepal Med Assoc. 2022 Jun 1; 60 (250): 541545541-545.

IntroductionAcute exacerbation of chronic obstructive pulmonary disease is a life-threatening condition triggered by infections or non-infectious agents. Antibiotics use in such cases prevents severe deterioration and treatment failure. Past studies have shown inappropriate use of antibiotics in different health care settings. The objective of this study was to find out the prevalence of antibiotics use in patients with acute exacerbation of chronic obstructive pulmonary disease in the Department of Internal Medicine of a tertiary care centre.MethodsA descriptive cross-sectional study was conducted among patients with acute exacerbation of Chronic Obstructive Pulmonary Disease admitted to Department of Internal Medicine of a tertiary care centre from 12th February, 2022 to 15th April, 2022 after taking ethical clearance from Institutional Review Committee (Reference number: 417). Convenience sampling was done. Data analysis was done using the Statistical Package for the Social Sciences version 23.0. Point estimate at 95% Confidence Interval was calculated along with frequency and percentage for binary data along with median and interquartile range for continuous data.ResultsThe prevalence of antibiotics use among study participants was 106 (98.15%) (95.61-100 at a 95% Confidence Interval). Penicillin 82 (75.93%) was the most commonly used antibiotics group.ConclusionsThe use of antibiotics in acute exacerbation of chronic obstructive pulmonary disease was higher as compared to other similar studies.Keywordsanti-bacterial agents; chronic obstructive pulmonary disease; guideline adherence.

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