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- Taro Horino, Tomohiro Eguchi, Satoshi Inotani, Akira Hirose, Masayuki Ishihara, Kenichi Yagyu, Kazushige Uchida, Mikiya Fujieda, and Yoshio Terada.
- Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Japan.
- Intern. Med. 2023 Jan 1; 62 (1): 919491-94.
AbstractVascular endothelial growth factor inhibitors and checkpoint inhibitors are effective treatments for solid tumors. These new classes of anti-cancer agents frequently cause kidney-related side effects. Although their anti-cancer effects may be enhanced when used in combination, the severity of their kidney-related side effects is unknown. We herein report the first case of thrombotic microangiopathy and mesangial proliferative glomerulonephritis caused by combined treatment with atezolizumab and bevacizumab in a 74-year-old man with hepatocellular carcinoma. The combination therapy was discontinued and replaced with intravenous methylprednisolone followed by oral prednisolone. Subsequently, the urinary protein excretion levels declined.
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