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- Kenichiro Takeda, Akira Naito, Toshihiko Sugiura, Masaki Ishige, Kohei Shikano, Mitsuhiro Abe, Hajime Kasai, Shota Miyakuni, Shu Yamashita, Ayako Shigeta, Seiichiro Sakao, and Takuji Suzuki.
- Department of Respirology, Graduate School of Medicine, Chiba University, Japan.
- Intern. Med. 2023 Jan 15; 62 (2): 275279275-279.
AbstractWe herein report a case of pulmonary veno-occlusive disease (PVOD) induced by allo-hematopoietic stem cell transplantation (HSCT) in a 48-year-old man who was diagnosed with acute myeloid leukemia. Five months after transplantation, he developed dyspnea and was diagnosed with pulmonary hypertension based on right heart catheterization. Although he received treatment with pulmonary vasodilators, diuretics, and corticosteroids, his pulmonary artery pressure did not decrease, and his pulmonary edema worsened. Based on the clinical course, hypoxemia, diffusion impairment, and computed tomography findings, the patient was diagnosed with HSCT-related PVOD. Critical attention should be paid to dyspnea after HSCT for the early diagnosis of PVOD.
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