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Case Reports
In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft.
- Lijun Zhang, Guangchao Xu, Yating Wei, Mingzhou Yuan, Yuanyuan Li, Meifang Yin, Chufen Chen, Guangtao Huang, Bin Shu, and Jun Wu.
- Department of Burns and Plastic Surgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, P.R. China.
- Int J Med Sci. 2022 Jan 1; 19 (5): 952-964.
AbstractPreventing fibrosis or hypertrophic scar formation following tissue damage is still a big challenge despite the numerous approaches clinicians currently use. Hitherto, no written account was available of a successful case of scarless skin healing after a severe burn injury. Here, we report the first case of the "perfect regenerative healing" of a severe burn wound with no hypertrophic scar formation in which a postage stamp skin autograft was covered with human cytotoxic-T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) gene-transferred pig skin. We also discuss the mechanisms involved in the scarless healing of human burn wounds.© The author(s).
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