• Natalija Novokmet, Ana Galov, Vedrana Škaro, Petar Projić, Jelena Šarac, Dubravka Havaš Auguštin, Pavao Rudan, Dragan Primorac, and Damir Marjanović.
• Natalija Novokmet, Institute for Anthropological Research, Ljudevita Gaja 32, 10000 Zagreb, Croatia, natalija.novokmet@inantro.hr.
• Croat. Med. J. 2022 Jun 22; 63 (3): 231-243.

AimTo use the method of meta-analysis to assess the influence of island population isolation on the sub-structuring of the Croatian population, as well as the influence of regional population groups on the sub-structuring of the Southeastern European population with regard to basic population genetic statistical parameters calculated by using STR locus analysis.MethodsBio-statistical analyses were performed for 2877 unrelated participants of both sexes from Southeastern Europe. Nine autosomal STR loci (D3S1358, vWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317, and D7S82) were analyzed by using standard F-statistics and population structure analysis (Structure software).ResultsGenetic differentiation of Croatian subpopulations assessed with the FST method was higher at the level of the Croatian population (0.005) than at the level of Southeastern Europe (0.002). The island of Vis showed the most pronounced separation in the Croatian population, and Albanians from Kosovo in the population of Southeast Europe, followed by Croatia, Bosnia and Herzegovina, and Hungary.ConclusionThe higher structure of Croatian subpopulations in relation to Southeastern Europe suggest a certain degree of genetic isolation, most likely due to the influence of endogamy within rural island populations.

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