• Jacob Blankenberger, Marco Kaufmann, Emiliano Albanese, Rebecca Amati, Daniela Anker, Anne-Linda Camerini, Patricia Chocano-Bedoya, Stéphane Cullati, Alexia Cusini, Jan Fehr, Erika Harju, Philipp Kohler, Susi Kriemler, Gisela Michel, Nicolas Rodondi, Pierre-Yves Rodondi, Alexandre Speierer, Stefano Tancredi, Milo A Puhan, Christian R Kahlert, and Corona Immunitas Research Group.
• Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland.
• Bmc Med. 2022 Jun 20; 20 (1): 233.

BackgroundWe aimed to determine whether living in a household with children is associated with SARS-CoV-2 seropositivity in adults and investigated interacting factors that may influence this association.MethodsSARS-CoV-2 serology testing was performed in randomly selected individuals from the general population between end of October 2020 and February 2021 in 11 cantons in Switzerland. Data on sociodemographic and household characteristics, employment status, and health-related history was collected using questionnaires. Multivariable logistic regression was used to examine the association of living with children <18 years of age (number, age group) and SARS-CoV-2 seropositivity. Further, we assessed the influence of reported non-household contacts, employment status, and gender.ResultsOf 2393 working age participants (18-64 years), 413 (17.2%) were seropositive. Our results suggest that living with children and SARS-CoV-2 seropositivity are likely to be associated (unadjusted odds ratio (OR) 1.22, 95% confidence interval [0.98-1.52], adjusted OR 1.25 [0.99-1.58]). A pattern of a positive association was also found for subgroups of children aged 0-11 years (OR 1.21 [0.90-1.60]) and 12-17 years (OR 1.14 [0.78-1.64]). Odds of seropositivity were higher with more children (OR 1.14 per additional child [1.02-1.27]). Men had higher risk of SARS-CoV-2 infection when living with children than women (interaction: OR 1.74 [1.10-2.76]).ConclusionsIn adults from the general population living with children seems associated with SARS-CoV-2 seropositivity. However, child-related infection risk is not the same for every subgroup and depends on factors like gender. Further factors determining child-related infection risk need to be identified and causal links investigated.Trial Registrationhttps://www.isrctn.com/ISRCTN18181860 .© 2022. The Author(s).

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