• Eur. J. Clin. Invest. · Apr 2019

    Review Meta Analysis

    Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta-analysis.

    • Cuifang He, Peihuan Lin, Wenbing Liu, and Kuaifa Fang.
    • Department of CCU, The No.6 People's Hospital, Huizhou, China.
    • Eur. J. Clin. Invest. 2019 Apr 1; 49 (4): e13074.

    BackgroundThe prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) is conflicting. This meta-analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS.MethodsA comprehensive literature search was performed in Pubmed, Embase, VIP, CNKI and WanFang databases up to 16 June 2018. All observational studies that investigated the prognostic value of hyperuricemia in ACS patients were selected. Outcome of interests was major adverse cardiovascular events (MACEs), all-cause mortality or cardiovascular mortality.ResultsA total of nine studies enrolling 8776 ACS patients were included and analysed. ACS patients with hyperuricemia had an increased risk of MACEs (risk ratio [RR]: 1.86; 95% confidence intervals [CI]: 1.47-2.35), all-cause mortality (RR 1.86; 95% CI: 1.49-2.32) and cardiovascular mortality (RR: 1.74; 95% CI: 1.36-2.22) after adjustment for the conventional risk factors. Stratified analysis showed that the prognostic significance of hyperuricemia was consistently observed in each subgroups.ConclusionsThis meta-analysis suggests that hyperuricemia independently predicts MACEs and death in ACS patients. Determination of uric acid level has potential to improve risk stratification of adverse outcomes in ACS patients.© 2019 Stichting European Society for Clinical Investigation Journal Foundation.

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