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- Niccolò Terrando and Katerina Akassoglou.
- Department of Anesthesiology, Cell Biology, and Immunology, Duke University Medical Center, Durham, NC, USA. Electronic address: niccolo.terrando@duke.edu.
- Br J Anaesth. 2022 Aug 1; 129 (2): 147150147-150.
AbstractSystemic perturbations such as peripheral surgical trauma induce neurovascular, inflammatory, and cognitive changes. The blood-brain barrier is a key interface between the periphery and the central nervous system, and is critically involved in regulating neuroimmune interactions to maintain overall homeostasis. Mounting evidence suggests that blood-brain barrier dysfunction is a hallmark of ageing and multiple neurological conditions including Alzheimer's disease. We discuss a recent study published in the British Journal of Anaesthesia that describes blood-brain barrier changes and neuroinflammation in patients with postoperative delirium after non-intracranial surgery.Copyright © 2022 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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