• Burns · Jun 2023

    Human skin processing affects clinical outcome in allograft recipients.

    • Barbara Antonioli, Marta Cecilia Tosca, Basilio Pintaudi, Francesco Guidoni, Marta Galuzzi, Chiara Pelizzoni, Benedetto Manasseri, Maria Chiara Grimaldi, Giovanni Sesana, and Federico Bertuzzi.
    • Tissue Bank and Tissue Therapy Unit, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy. Electronic address: barbara.antonioli@ospedaleniguarda.it.
    • Burns. 2023 Jun 1; 49 (4): 797805797-805.

    AbstractSkin allografts represent a milestone in burn patient treatment. However, skin procurement is still burdened by high rates of contamination, and validation procedures have not yet been standardized. In addition, it is not clear if tissue viability affects allograft skin outcomes. In 2120 skin samples from 610 donors, a retrospective analysis was performed to identify donor and procurement variables associated with bacterial contamination and tissue viability. Post-processing contamination was associated significantly with the donor type, cause of death, length of hospitalization, procurement site, surgeon, interval between procurement and banking, and decontamination method. Tissue viability appeared to be negatively associated with freezing. In two series of skin allograft recipients (155 and 195 patients), we evaluated the role of skin characteristics and procurement variables on clinical outcomes. We found that the length of hospitalization was associated significantly with donor age. Procalcitonin and PCR values in allograft recipients were correlated with the decontamination method. No significant associations were observed between tissue viability and clinical outcomes (length of hospitalization, cause of donor death, or inflammatory parameters) after allograft transplantation. In these large case series, we identified donor and procurement variables that may affect allograft skin recipients. The decontamination method appeared to be a critical step for skin allograft requiring better standardization.Copyright © 2022 Elsevier Ltd and ISBI. All rights reserved.

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