• Vadim S Gadzhiagaev, Oleg D Shekhtman, Anton N Konovalov, Shalva S Eliava, Yuri V Pilipenko, Dmitriy N Okishev, and Yulia V Strunina.
• Department of Cerebrovascular Surgery, Burdenko Neurosurgical Center, Moscow, Russian Federation. Electronic address: vgadzhiagaev@yandex.ru.
• World Neurosurg. 2022 Sep 1; 165: e298e310e298-e310.

ObjectiveAnalysis of results of surgical treatment of 112 patients with large and giant anterior cerebral artery (ACA) aneurysms.MethodsThis is the largest clinical series of large and giant ACA aneurysms ever reported. Retrospective analysis of medical charts, radiographic studies, and intraoperative videos was performed. Univariate and multivariate analysis of relations among 3 types of outcomes (complete aneurysm occlusion, ischemic complications, and clinical outcomes) and predicting factors was performed.ResultsMost aneurysms were communicant (84.8%). Aneurysms of the A1 segment and distal segments (A2-A5) were encountered rarely. Complete aneurysm occlusion (class I) was shown in 95 cases (90.5%). In 4 patients, only exploration and wrapping were performed because of severe atherosclerosis and chronic intraluminal thrombi. Partial occlusion (class III) was shown in 2 patients, and neck residual (class II) in 4 patients. Cerebral ischemia developed in 29 patients postoperatively. Occlusion or injury of the A1 segment and anterior communicating artery perforators and recurrent branch of Heubner were the most common reason for ischemic complications. At follow-up, 97 patients (86.6%) had favorable outcomes. Ten patients (8.9%) had unfavorable outcomes because of postoperative complications.ConclusionsMicrosurgery provides effective and relatively safe occlusion of complex ACA aneurysms. Direct clipping can be applied in most cases independent of their precise location. In certain cases, alternative methods can be safely used. According to multivariate analysis, giant aneurysm size, aneurysm-related mass effect, involvement of large arterial branches in the aneurysm wall, and intraoperative complications were significant predicting factors for ischemic complications.Copyright © 2022 Elsevier Inc. All rights reserved.

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