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- Takahiko Hashimoto, Kosuke Takahashi, Sachiko Ota, Nobumasa Okumura, Haruka Kondo, Asuki Fukatsu, and Toru Hara.
- Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan.
- Intern. Med. 2023 Jan 15; 62 (2): 281284281-284.
AbstractCrizotinib shows antitumor activity against C-ros oncogene 1-rearranged non-small-cell lung cancer (NSCLC). While corrected QT interval (QTc) prolongation and bradycardia are known as cardiac adverse effects, little is known about crizotinib-related heart failure. Our patient with C-ros oncogene 1-rearranged NSCLC on a reduced dose of crizotinib (200 mg twice daily) after initially experiencing bradycardia and QTc prolongation developed crizotinib-induced heart failure. With further dose reduction (250 mg once daily), there was no recurrence of any cardiac adverse effects, and the patient achieved a long-term response. Although crizotinib can cause heart failure, continuation of crizotinib at a low dose may be an effective treatment option.
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