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- Yuri Tsuboi, Yumoe Iimura, Fumiaki Matsumura, Toru Nanmoku, Sakurako Suma, Ryota Matsuoka, Tomoki Nakagawa, Daishi Nakagawa, Yasuhito Suehara, Keiichiro Hattori, Kimi Sato, Yumiko Maruyama, Tatsuhiro Sakamoto, Yasuhisa Yokoyama, Takayasu Kato, Naoki Kurita, Hidekazu Nishikii, Naoshi Obara, Masaki Ieda, Shigeru Chiba, and Mamiko Sakata-Yanagimoto.
- Department of Hematology, University of Tsukuba Hospital, Japan.
- Intern. Med. 2023 Feb 15; 62 (4): 595600595-600.
AbstractAngioimmunoblastic T-cell lymphoma (AITL) is an intractable type of T-cell lymphoma. We and others have identified that the p.Gly17Val RHOA mutation is specifically identified in AITL. We herein report a patient whose condition deteriorated, resulting from massive pericardial effusion one month after undergoing autologous transplantation for AITL. He was diagnosed with cardiac tamponade caused by AITL recurrence in the presence of the p.Gly17Val RHOA mutation as well as T-lineage cells with an aberrant immune-phenotype in the pericardial effusion. This case suggests that a precision medicine approach by detecting the presence of a p.Gly17Val RHOA mutation is useful for the management of AITL.
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