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- Ryutaro Hirama, Masato Kono, Takeshi Kobayashi, Yuiko Oshima, Kenichiro Takeda, Koichi Miyashita, Hideki Miwa, Akari Tsutsumi, Yoshihiro Miki, Dai Hashimoto, Yoshiro Otsuki, and Hidenori Nakamura.
- Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Japan.
- Intern. Med. 2023 Feb 1; 62 (3): 423429423-429.
AbstractA 71-year-old man was admitted for left-sided chest pain. He had a history of diabetes, treatment with epidermal growth factor receptor-tyrosine kinase inhibitor for advanced non-small-cell lung cancer, and corticosteroid treatment for underlying lung diseases. Chest computed tomography showed consolidations in the bilateral lower lobes, and Aspergillus fumigatus was detected by bronchoscopy. Invasive pulmonary aspergillosis was suspected, and antifungal therapy with voriconazole was initiated; however, the patient passed away suddenly. Autopsy revealed disseminated Aspergillus infection and intra-abdominal hemorrhage due to the rupture of a splenic vein aneurysm caused by Aspergillus necrotizing vasculitis, which was considered the cause of death.
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