• Ups. J. Med. Sci. · Jan 2022

    The impact of splenectomy on human lipid metabolism.

    • Orgun Gunes, Emre Turgut, Yusuf Murat Bag, Ersin Gundoğan, Ajda Gunes, and Fatih Sumer.
    • Department of Gastrointestinal Surgery, Atatürk Training and Research Hospital, Izmir, Turkey.
    • Ups. J. Med. Sci. 2022 Jan 1; 127.

    BackgroundSplenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism.MethodsThe data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight patients whose serum lipid values were measured both preoperatively and 1 year after surgery were included in this study.ResultsSignificantly higher levels of total cholesterol, low-density lipoprotein (LDL), and non-high-density lipoprotein (HDL) lipid profile were found in the postsplenectomy measurements. However, no significant differences were recorded in levels of triglyceride, HDL, or very-LDL.ConclusionWe determined that splenectomy does impact lipid metabolism, and that the metabolic effects of splenectomy should further be investigated.© 2022 The Author(s). Published by Upsala Medical Society.

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