• Moritz Flick, Tim-Henrik Schreiber, Jonathan Montomoli, Linda Krause, Hans D de Boer, Karim Kouz, ScheerenThomas W LTWL, Can Ince, Matthias P Hilty, and Bernd Saugel.
• From the Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (MF, THS, KK, BS), Department of Intensive Care, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (JM, CI), Department of Anesthesia and Intensive Care, Infermi Hospital, AUSL Romagna, Rimini, Italy (JM), Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (LK), Department of Anesthesiology, Pain Medicine and Procedural Sedation and Analgesia, Martini General Hospital Groningen, Groningen, the Netherlands (HDdB), Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (TWLS), Institute of Intensive Care Medicine, University Hospital of Zurich, Zurich, Switzerland (MH) and Outcomes Research Consortium, Cleveland, Ohio, USA (BS).
• Eur J Anaesthesiol. 2022 Jul 1; 39 (7): 582590582-590.

BackgroundHandheld vital microscopy allows direct observation of red blood cells within the sublingual microcirculation. Automated analysis allows quantifying microcirculatory tissue perfusion variables - including tissue red blood cell perfusion (tRBCp), a functional variable integrating microcirculatory convection and diffusion capacities.ObjectiveWe aimed to describe baseline microcirculatory tissue perfusion in patients presenting for elective noncardiac surgery and test that microcirculatory tissue perfusion is preserved during elective general anaesthesia for noncardiac surgery.DesignProspective observational study.SettingUniversity Medical Center Hamburg-Eppendorf, Hamburg, Germany.Patients120 elective noncardiac surgery patients (major abdominal, orthopaedic or trauma and minor urologic surgery) and 40 young healthy volunteers.Main Outcome MeasuresWe measured sublingual microcirculation using incident dark field imaging with automated analysis at baseline before induction of general anaesthesia, under general anaesthesia before surgical incision and every 30 min during surgery. We used incident the dark field imaging technology with a validated automated analysis software.ResultsA total of 3687 microcirculation video sequences were analysed. Microcirculatory tissue perfusion variables varied substantially between individuals - but ranges were similar between patients and volunteers. Under general anaesthesia before surgical incision, there were no important changes in tRBCp, functional capillary density and capillary haematocrit compared with preinduction baseline. However, total vessel density was higher and red blood cell velocity and the proportion of perfused vessels were lower under general anaesthesia. There were no important changes in any microcirculatory tissue perfusion variables during surgery.ConclusionIn patients presenting for elective noncardiac surgery, baseline microcirculatory tissue perfusion variables vary substantially between individuals - but ranges are similar to those in young healthy volunteers. Microcirculatory tissue perfusion is preserved during general anaesthesia and noncardiac surgery - when macrocirculatory haemodynamics are maintained.Copyright © 2022 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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