• Fırat Narin, Sinan Bahadir, Şahin Hanalioğlu, Dicle Karakaya, Ibrahim Başar, Ilkay Işikay, Figen Söylemezoğlu, Nejat Akalan, and Burçak Bilginer.
• Department of Neurosurgery, Ministry of Health Ankara City Hospital, Ankara, Turkey.
• World Neurosurg. 2022 Sep 1; 165: e469e478e469-e478.

ObjectiveTo share our clinical experience of 25 years and identify prognostic factors for progression-free and overall survival in pediatric intracranial ependymomas.MethodsIn total, 61 children who were treated between 1995 and 2020 in a single institution were included in the study. Medical records of the patients were retrospectively reviewed to obtain and analyze the following data: patient age at first surgery, sex, presenting symptoms, hydrocephalus and any invasive treatment, anatomic site, extent of resection, pathologic grade, time to progression, and time to death. Progression-free and overall survival rates and affecting factors were analyzed by Kaplan-Meier method.ResultsDysphagia, number of surgeries, and spinal seeding were associated with progression free and overall survival in univariate analysis. The extent of resection, World Health Organization grade, and visual problems were also associated with progression whereas sex was associated with overall survival. Cox regression identified the extent of resection and single surgery as an independent prognostic factor for progression-free survival. No independent factor was found for overall survival.ConclusionsThis single center experience of 25 years confirms the beneficial effect of gross total resection on disease progression. Although spinal seeding seems to affect survival rates, greater number of cases are needed to reveal its full effect.Copyright © 2022 Elsevier Inc. All rights reserved.

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