• Jianxun Zhu, Xiaoru Xu, Xin Zhang, Yue Zhuo, Shaotao Chen, Chongwen Zhong, Mingjun Liu, and Zhihong Wang.
• Changchun University of Chinese Medicine, Jingyue Economic Development District, Changchun, People's Republic of China.
• Medicine (Baltimore). 2022 Jul 1; 101 (26): e29767e29767.

BackgroundGinseng has been believed to provide energy, physical health, and well-being to patients for hundreds of years. Fatigue is a multidimensional symptom with unknown etiology and varying severity, and lots of patients suffer from fatigue.MethodsWe search for research of ginseng treatment of disease-related fatigue in adult patients in Pubmed, Embase, Medline, and Cochrane library. Two independent reviewers assessed included studies and met to develop consensus on included studies. And we used Review Manager 5.3 software to evaluate the risk of bias.ResultsThe present meta-analysis included 12 randomized controlled trial containing 1298 patients. In the fixed-effect meta-analysis of 12 randomized controlled trial, ginseng supplements had a statistically significant efficacy on disease-related fatigue reduction (standardized mean difference = 0.33, 95% confidence interval = 0.44-0.22).ConclusionsThe use of ginseng supplements is benefit for patients to reduce disease-related fatigue.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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