• Medicine · Jul 2022

    Case Reports

    Coexistence of submandibular epithelioid angiosarcoma and papillary thyroid carcinoma: A case report.

    • Yi-Ting Liu, Jing Wang, Yan-Xia Sui, and Dong-Li Zhao.
    • Department of Oncological Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
    • Medicine (Baltimore). 2022 Jul 1; 101 (26): e29341e29341.

    IntroductionReports on the coexistence of epithelioid angiosarcoma (EA) and papillary thyroid carcinoma (PTC) are rare. Over the past 50 years, only 2 cases of coexistence of EA and PTC have been reported in English literature. Therefore, we report a rare case of coexistence of EA and PTC treated with surgery and adjuvant radiation therapy.Patient ConcernsA 64-year-old man visited our hospital with a painless mass in the left submandibular gland, with poor mobility.DiagnosisNeck ultrasonography revealed nodules in the left submandibular gland and multiple cystic-solid mixed nodules in the left thyroid gland. Pathological findings revealed coexistence of EA in the left submandibular gland area and PTC in the left thyroid gland.InterventionsThe patient underwent resection of the left submandibular gland, deep maxillofacial tumor, total thyroidectomy, left neck I, II, III, and VI regional lymph node dissection, and recurrent laryngeal nerve exploration under general anesthesia. Two months postoperatively, the patient also received adjuvant radiation therapy in the local and adjacent areas, with 4MV-X IMRT DT50GY at 2Gy/day 25 fractions.OutcomesThe follow-up period was 37 months. The patient recovered well without focal neurological deficits, local recurrence, or distant metastasis after surgery, except for grade I skin reaction after adjuvant radiation therapy.ConclusionsThis is a rare case report of the coexistence of EA in the left submandibular gland and PTC in the left thyroid gland. Although multiple examinations were used, precise preoperative diagnosis was challenging owing to the coexistence of EA and PTC. Surgery and radiotherapy were effective treatments for the coexistence of EA and PTC in this case.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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