• Karla Arévalo Ruales, José Ivorra Cortés, Elena Grau García, César David Vera Donoso, Antonio José Cañada Martínez, and Román IvorraJosé AndrésJADepartamento de Reumatología, Hospital Universitario y Politécnico La Fe, Valencia, España..
• Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, España. Electronic address: karlaarevalorualed@gmail.com.
• Med Clin (Barc). 2023 Jan 20; 160 (2): 515951-59.

ObjectivesTo evaluate the aspects of the basal bone health status in prostate cancer patients. Furthermore, to evaluate in a real-world setting the effect of different schemes (intermittent or continuous) of androgen deprivation therapy (ADT) and the effect of denosumab in bone mass density (BMD).MethodsObservational, retrospective study of a cohort of prostate cancer patients in treatment with luteinizing hormone-releasing hormone (LH-RH) agonists, evaluated in the rheumatology department of a tertiary center. Demographics, FRAX score, LH-RH treatment scheme, osteoporosis treatment, laboratory data and BMD were collected. Mixed effect regression models to analyze the interaction between LH-RH treatment scheme, denosumab and BMD evolution were used.ResultsEighty-three patients (mean age 71±8years) were included. At the basal evaluation, 16% of patients presented densitometric osteoporosis and 27% of patients presented high fracture risk. Eighty percent of patients had inadequate vitaminD levels. VitaminD >30ng/mL was correlated with higher T-scores. There was no association between LH-RH treatment scheme and BMD evolution, however there was a positive association with denosumab.ConclusionA high proportion of patients presented elevated fracture risk or inadequate vitaminD levels, not previously recognized. Bone health assessment and fracture risk evaluation are convenient in these patients. In a real-world setting, the effect of denosumab in BMD is detected, however the effect of intermittent LH-RH schema treatment is less evident.Copyright © 2022 Elsevier España, S.L.U. All rights reserved.

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