• J. Intern. Med. · Oct 2022

    Case Reports

    Early SARS-CoV-2 associated acute transverse myelitis: A case for neurotropism?

    • Irene F Lu, Jack S Cornish, Aadith Ashok, Siew Kar Chen, Eugene Athan, and Andrew Hughes.
    • Barwon Health, University Hospital Geelong, Geelong, Australia.
    • J. Intern. Med. 2022 Oct 1; 292 (4): 679-683.

    AbstractThere are increasing reports of immune-mediated and para-infectious syndromes beyond the well-known respiratory manifestations of severe-acute-respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the spectrum of severe neurological sequelae of SARS-CoV-2 remains undefined. We present the case of a 66-year-old female with rapidly progressive lower limb neurology 3 days post SARS-CoV-2 infection. Clinical and radiological findings were in keeping with transverse myelitis and treatment success was achieved with methylprednisolone and remdesivir. This report will discuss the associations between SARS-CoV-2 and acute transverse myelitis. We believe this is one of few described cases of early SARS-CoV-2-associated transverse myelitis secondary to neurotropism and the first successfully treated with the inclusion of remdesivir in the therapeutic regimen.© 2022 The Association for the Publication of the Journal of Internal Medicine.

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