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- Hiroko Iizuka-Honma, Haruko Takizawa, Toru Mitsumori, Hidehiro Okura, Hisato Ishii, and Masaaki Noguchi.
- Department of Hematology, Juntendo University Urayasu Hospital, Japan.
- Intern. Med. 2023 Feb 1; 62 (3): 459463459-463.
AbstractMany patients with primary vitreoretinal lymphoma (PVRL) exhibit central nervous system (CNS) involvement either at the diagnosis or during follow-up. The prognosis in the patients of PVRL with relapsed or refractory CNS remains extremely poor. We herein report a patient with refractory PVRL who had recurrence in the spinal cord despite receiving high-dose methotrexate-based chemotherapy and whole-brain radiotherapy. The patient surprisingly responded to tirabrutinib temporarily. We believe that this case suggests the utility of this new target therapy.
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