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Internal medicine journal · Jul 2022
Upfront tandem autologous non-myeloablative allogeneic stem cell transplant in high-risk multiple myeloma: a long-term single-centre experience.
- Phillip C Nguyen, Jenny Muirhead, Joanne Tan, Anna Kalff, Krystal Bergin, Patricia Walker, and Andrew Spencer.
- Department of Clinical Haematology, Alfred Health, Melbourne, Victoria, Australia.
- Intern Med J. 2022 Jul 1; 52 (7): 1263-1267.
AbstractThe role of upfront non-myeloablative allogeneic stem cell transplantation (NMA alloSCT) in high-risk multiple myeloma (HR-MM) is unclear. We evaluated outcomes of NMA alloSCT following autologous stem cell transplant (ASCT) compared with ASCT alone for newly diagnosed HR-MM. Two-year progression-free survival was improved in the ASCT-NMA alloSCT group (44% vs 16%; P = 0.035), with a trend for improved overall survival (P = 0.118). These results suggest that ASCT-NMA alloSCT can be considered as upfront therapy in HR-MM.© 2022 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.
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