• Ulrich Pecks, Nadine Mand, Thomas Kolben, Mario Rüdiger, Peter Oppelt, Janine Zöllkau, Astrid Dempfle, and The CRONOS registry.
• Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Kiel; Center for Pediatric and Adolescent Medicine, University Hospital Gießen and Marburg GmbH, Philipps University Marburg; Department of Gynecology and Obstetrics, LMU Medical Center, Munich; Neonatology and Pediatric Intensive Care Medicine, Department of Pediatric and Adolescent Medicine, Medical Faculty, Technical University of Dresden; Center for Fetal and Neonatal Health, Technical University of Dresden; Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Johannes Kepler University, Linz, Austria; Department of Obstetrics, University Hospital Jena; Institute for Medical Informatics and Statistics, University Hospital Schleswig-Holstein, Kiel.
• Dtsch Arztebl Int. 2022 Sep 5; 119 (35-36): 588594588-594.

BackgroundUsing data from the German CRONOS registry, we assessed the risk of a complicated course of COVID-19 in women with a SARS-CoV-2-infection during pregnancy, with particular consideration of gestational age, vaccination status, and pandemic dynamics.MethodsData acquired in two separate periods (March 2020 to August 2021; January to June 2022) for CRONOS, a prospective, hospital-based observational study (DRKS00021208), were studied with logistic regression models. Odds ratios comparing 32 with 22 weeks of gestation were calculated for relevant COVID-19-specific events occurring within 4 weeks of a positive test result.ResultsData from 3481 women were evaluated. The risk of all of the defined COVID-19-specific events was low among women who became ill with COVID-19 during the first trimester and rose with increasing gestational age into the early third trimester. For example, the odds ratio for hospitalization because of a COVID-19 infection, comparing 32 versus 22 weeks of gestation, was 1.4 (95% confidence interval [1.2; 1.7]). This risk was lower in the second period of data acquisition than in the first (OR 0.66; 95% CI [0.50; 0.88]), and it was even lower if the pregnant patient had been vaccinated against COVID-19 (OR 0.27; 95% CI [0.18; 0.41]).ConclusionThese findings can serve as a basis for counseling about prophylactic or therapeutic measures, such as the administration of monoclonal antibodies. They underscore the efficacy of vaccination for pregnant women even during the omicron phase of the pandemic.

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