• Murat Selçuk, Tufan Çınar, Faysal Şaylık, Tayyar Akbulut, Suha Asal, Vedat Çiçek, Mert İlker Hayıroğlu, and İbrahim Halil Tanboğa.
• Department of Cardiology, Health Sciences University, Sultan II, Abdülhamid Han Training and Research Hospital, Istanbul, Turkey.
• Rev Invest Clin. 2022 May 2; 74 (3): 156-164.

BackgroundThere is a lack of studies supporting the association between the uric acid/albumin ratio (UAR) and the development of new-onset atrial fibrillation (NOAF) in ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (pPCI).ObjectiveThe objective of the study was to assess the efficacy of the UAR for predicting the occurrence of NOAF in STEMI patients undergoing pPCI.MethodsWe recruited 1484 consecutive STEMI patients in this retrospective and cross-sectional investigation. The population sample was classified based on the development of NOAF during hospitalization. NOAF was defined as an atrial fibrillation (AF) observed during hospitalization in patients without a history of AF or atrial flutter. The UAR was computed by dividing the serum uric acid (UA) level by serum albumin level.ResultsAfter pPCI, 119 STEMI patients (8%) were diagnosed with NOAF. NOAF patients had higher serum UAR levels than individuals who did not have NOAF. According to the multivariable logistic regression model, the UAR was an independent predictor for NOAF in STEMI patients (OR: 6.951, 95% CI: 2.978-16.28, p < 0.001). The area under curve (AUC) value of the UAR in a receiver operating characteristics (ROC) evaluation was 0.758, which was greater than those of its components (albumin [AUC: 0.633] and UA [AUC: 0.647]) and C-reactive protein (AUC: 0.714). The optimal UAR value in predicting NOAF in STEMI patients was greater than 1.39, with a sensitivity of 69% and a specificity of 74.5%.ConclusionTo the best of our knowledge, this is the first study indicating that the UAR was an independent predictor of NOAF development in STEMI patients.

15 keywords...

hide…