• Yating Wei, Jun Wu, Yuxin Chen, Kunwu Fan, Xuming Yu, Xiaojian Li, Yaohua Zhao, Yi Li, Guozhong Lv, Guodong Song, Xinzhou Rong, Cai Lin, Haitao Wang, Xiaodong Chen, Pihong Zhang, Chunmao Han, Hongxu Zu, Wenjun Liu, Yi Zhang, Chang Liu, Yongtao Su, Baolin Zhang, Bingwei Sun, Lei Wang, Wen Lai, Jinhui Liu, Chengde Xia, Geng Ji, Feng Zhu, Jia'ao Yu, Akebaer Ahemaiti, Hu Dong, Mingxia Chen, and PL-5 Investigators.
• Department of Burn and Plastic Surgery, Department of Wound Repair, Shenzhen Institute of Translational Medicine, the First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, China.
• Ann. Surg. 2023 Jan 1; 277 (1): 434943-49.

ObjectiveTo assess the safety and efficacy of antimicrobial peptide PL-5 (Peceleganan) spray in the treatment of wound infections.BackgroundAntimicrobial peptide PL-5 spray is a novel topical antimicrobial agent.MethodsWe conducted a multicenter, open-label, randomized, controlled phase IIb clinical trial to evaluate the efficacy and safety of PL-5 spray, as compared with silver sulfadiazine, in patients with skin wound infections. The primary efficacy outcome was the clinical efficacy rate on the first day after ending the treatment (D8). The secondary efficacy outcome was the clinical efficacy rate on the fifth day posttreatment (D5), the bacteria clearance rate, and the overall efficacy rate at the mentioned 2 time points. The safety outcomes included adverse reactions and pharmacokinetic analysis posttreatment.ResultsA total of 220 patients from 27 hospitals in China were randomly assigned to 4 groups. On D8, the efficacy rate was 100.0%, 96.7%, 96.7% for the 1‰ PL-5, 2‰ PL-5, 4‰ PL-5 groups, respectively, as compared with 87.5% for the control group. The efficacy rate among the 4 groups was significantly different ( P <0.05). On D5, the efficacy rate was 100.0%, 93.4%, 98.3% for the 1‰ PL-5, 2‰ PL-5, 4‰ PL-5 groups, respectively, as compared with 82.5% for the control group. The efficacy rate among the 4 groups was significantly different ( P <0.05). The blood concentration of PL-5 was not detectable in pharmacokinetic analysis. No severe adverse event related to the application of PL-5 was reported.ConclusionsAntimicrobial peptide PL-5 spray is safe and effective for the treatment of skin wound infections.Trial RegistrationChiCTR2000033334.Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

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