• Chun-Chieh Yang, Shih-Feng Weng, Kuei-Ling Tseng, and Chung-Han Ho.
• Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.
• Medicine (Baltimore). 2022 Jul 8; 101 (27): e29918e29918.

MethodsWe retrospectively analyzed 82 adult patients with MALA admitted to the ICU over 20 years. The association between the clinical parameters and mortality post-MALA was estimated using logistic regression analysis.ResultsPatients with MALA admitted to the ICU presented with clinical symptoms mainly associated with the head (40.24%), chest (41.46%), and abdomen (35.37%). Additionally, the PLL distribution significantly varied with age, APACHE II = Acute Physiology and Chronic Health Evaluation II (APACHE II) score, various laboratory parameters like nadir arterial bicarbonate level, multiple treatment modalities such as renal replacement therapy, and mortality. The overall mortality rate was 17.07%. After adjustment of age and gender, the significant predictors of mortality were APACHE II score, PLL, vasoactive support, ventilator support, and cardiopulmonary resuscitation.ConclusionsDespite MALA being a rare event, it is necessary to evaluate its clinical characteristics, especially the associated PLL and mortality. In the current study, higher levels of APACHE II score and PLL show a greater likelihood of mortality in MALA patients.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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