• Yan-Ying Huang, Wan-Rui Yang, Yan-Hua Geng, and Yue Zhang.
• Department of Pathology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, People's Republic of China.
• Medicine (Baltimore). 2022 Jul 8; 101 (27): e29861e29861.

RationaleAlveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma harboring an ASPL-TFE3 fusion gene. Herein, we report a case of ASPS associated with brain metastasis. Immunohistochemistry (IHC) for TFE3 antigen expression and fluorescence in situ hybridization (FISH) for TFE3 rearrangement were performed to arrive at an accurate diagnosis.Patient ConcernsA 47-year-old man was hospitalized for a headache and numbness of the lower limbs.DiagnosesPreoperative computed tomography and magnetic resonance imaging revealed 2 brain masses, 1 each in the right parietal and temporal bones. We diagnosed this case as ASPS with brain metastasis based on histological morphology, IHC, and FISH.InterventionsThe patient underwent right skull titanium mesh implantation and supratentorial superficial lesion resection.Outcomes: The patient recovered well after discharged from hospital.LessonsThe diagnosis of ASPS depends on careful clinical, radiographic, histopathological, IHC, and FISH assessments to arrive at the correct diagnosis. Thus, TFE3 may be useful in the diagnosis and treatment of ASPS.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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