• Internal medicine · Feb 2023

    Case Reports

    Development of Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome after Conversion from Plasmacytoma of Bone to Multiple Myeloma.

    • Keiko Hatano, Kenta Orimo, Mizuki Ogura, Shingo Okabe, Tadao Ishida, Akatsuki Kubota, Jun Shimizu, and Hideji Hashida.
    • Department of Neurology, Japanese Red Cross Medical Center, Japan.
    • Intern. Med. 2023 Feb 1; 62 (3): 475479475-479.

    AbstractA 36-year-old man developed polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome after conversion from solitary plasmacytoma of bone to multiple myeloma. Twenty-four days following the neurological onset, he lost his independent walking ability. The level of serum vascular endothelial growth factor (VEGF) at diagnosis was 5,250 pg/mL. Three months after initiating treatment, he regained his independent walking ability in line with a reduction in the elevated serum VEGF level. Due to their genomic instability gained during conversion, myeloma cells may overproduce humoral factors and cytokines, possibly contributing to the development of neuropathy as well as the production of VEGF.

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