• Jun Sasaki, Masaki Tominaga, Misa Sudou, Saeko Tokisawa, Yuuya Nishii, Yoshiaki Zaizen, Goushi Matama, Tomonori Chikasue, Kiminori Fujimoto, Kazuhiro Tabata, Junya Fukuoka, Tamiko Takemura, Tomotaka Kawayama, and Tomoaki Hoshino.
• Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
• Intern. Med. 2023 Feb 1; 62 (3): 439444439-444.

AbstractAn 82-year-old woman complained of recurring cough and shortness of breath and was diagnosed with progressive multiple myeloma (MM). Chest computed tomography (CT) revealed bilateral ground-glass opacity and interlobular septal thickening predominantly in the lower lung zones. Histopathologic findings obtained by a transbronchial lung cryobiopsy (TBLC) revealed alveolitis and granulomas consistent with granulomatous-lymphocytic interstitial lung disease (GLILD). Aggressive chemotherapy for MM contributed to the improvement in respiratory symptoms and abnormal chest CT findings. In cases of MM with lung abnormalities, the possibility of GLILD must be ruled out, and a TBLC should be considered to attain an accurate diagnosis.

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