• Boyu Wu, Lei Yang, Liying Chen, Lu Ma, and Yantao Guo.
• The First Affifiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province, China.
• Medicine (Baltimore). 2022 Jul 15; 101 (28): e29404e29404.

BackgroundKnee osteoarthritis (KOA) is a common cause of chronic musculoskeletal pain and disability as well as a socioeconomic burden on healthcare services globally. Numerous clinical trials indicated that traditional Chinese medicine (TCM) may effectively improve the clinical symptoms of KOA patients. However, the comparative efficacy and safety of different TCM therapies in patients with KOA is not yet clear. In order to evaluate the efficacy and safety of TCM for KOA, we will conduct a systematic review and network meta-analysis on the existing randomized controlled trials (RCTs).MethodsA systematic literature search will be conducted in PubMed, Web of Science, Embase, EBSCO, Cochrane Library, China National Knowledge Infrastructure, Wanfang, Chinese Biomedical Literature Database, and the VIP Database for Chinese Technical Periodicals up to February 2022 to identify the relevant RCTs. The primary outcomes are visual analog scale, Western Ontario and McMaster Universities Osteoarthritis Index, Lysholm score, and Lequesne index. Secondary outcomes include the total clinical effective rate and adverse events. Study quality will be evaluated using the Cochrane risk of bias tool (RoB 2.0) for RCTs. Data analysis will be performed using Stata and WinBUGS. The quality of evidence will be assessed using the Grades of Recommendations Assessment Development and Evaluation.ResultsThe results of this study will be submitted to a peer-reviewed journal for publication.ConclusionsThis study will provide evidence-based medical evidence for the treatment of KOA with TCM therapies and offer better assistance for clinical practice.Protocol Registration NumberINPLASY202230008.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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