• Medicine · Jul 2022

    Meta Analysis

    Postoperative radiotherapy in pIIIA-N2 non-small cell lung cancer after complete resection and adjuvant chemotherapy: A meta-analysis.

    • Shou-Feng Wang, Nai-Quan Mao, Wen-Hua Zhao, and Xin-Bin Pan.
    • Department of Thoracic surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.
    • Medicine (Baltimore). 2022 Jul 15; 101 (28): e29550e29550.

    BackgroundThis study aimed to evaluate the effect of postoperative radiotherapy (PORT) in patients with pIIIA-N2 non-small cell lung cancer after complete resection and adjuvant chemotherapy.MethodsElectronic databases (PubMed, Web of Science databases, Embase, and the Cochrane Central Register of Controlled Trials) were systematically searched to extract randomized control trials comparing PORT with observation in pIIIA-N2 non-small cell lung cancer patients until October 2021. Main outcomes were disease-free survival (DFS), overall survival (OS), and local recurrence.ResultsThree-phase 3 randomized control trials involving 902 patients were included: 455 patients in the PORT group and 447 patients in the observation group. The methodological quality of the 3 randomized control trials were high quality. The pooled analysis revealed that PORT decreased local recurrence rate (odds ratio = 0.56, 95% confidence interval [CI]: 0.40-0.76). However, PORT did not improve median DFS (hazard ratio = 0.84, 95% CI: 0.71-1.00) and OS (hazard ratio = 1.02, 95% CI: 0.68-1.52).ConclusionsPORT decreased the incidence of local recurrence. However, PORT did not improve DFS and OS.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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