• Rory B O'Donohoe, Hui Qing Lee, Terence Tan, Simon Hendel, Martin Hunn, Joseph Mathews, Mark Fitzgerald, Jeffrey V Rosenfeld, and Jin Tee.
• National Trauma Research Institute (NTRI), Melbourne, Australia; The University of Notre Dame, School of Medicine, Sydney, Australia. Electronic address: rbodonohoe@gmail.com.
• World Neurosurg. 2022 Oct 1; 166: e521e527e521-e527.

BackgroundAlthough it is often assumed that preinjury anticoagulant (AC) or antiplatelet (AP) use is associated with poorer outcomes among those with acute subdural hematoma (aSDH), previous studies have had varied results. This study examines the impact of preinjury AC and AP therapy on aSDH thickness, 30-day mortality, and extended Glasgow Outcome Scale at 6 months in elderly patients (aged ≥65).MethodsA level 1 trauma center registry was interrogated to identify consecutive elderly patients who presented with moderate or severe traumatic brain injury (TBI) and associated traumatic aSDH between the first of January 2013 and the first of January 2018. Relevant demographic, clinical, and radiological data were retrieved from institutional medical records. The 3 primary outcome measures were aSDH thickness on initial computed tomography scan, 30-day mortality, and unfavorable outcome at 6 months (extended Glasgow Outcome Scale).ResultsOne hundred thirty-two elderly patients were admitted with moderate or severe TBI and traumatic aSDH. The mean (±SD) age was 78.39 (±7.87) years, and a majority of patients (59.8%, n = 79) were male. There was a statistically significant difference in mean aSDH thickness, but there were no significant differences in 30-day mortality (P = 0.732) and unfavorable outcome between the AP, AC, combined AP and AC, and no antithrombotic exposure groups (P = 0.342).ConclusionsFurther studies with larger sample sizes are necessary to confirm these observations, but our findings do not support the preconceived notion in clinical practice that antithrombotic use is associated with poor outcomes in elderly patients with moderate or severe TBI.Copyright © 2022 Elsevier Inc. All rights reserved.

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