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- Xiao-Yang Chen, Aye Aye Thike, Johnathan Xiande Lim, Boon Huat Bay, and Puay Hoon Tan.
- Division of Pathology, Singapore General Hospital; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
- Singap Med J. 2023 Aug 1; 64 (8): 493496493-496.
IntroductionMicroinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and molecular markers.MethodsThe number of Mi foci in a cohort of 66 DCIS-Mi cases was assessed from haematoxylin and eosin-stained sections. Disease-free survival, clinicopathological parameters and biomarker expression were correlated with the number of Mi foci.ResultsHigher numbers of Mi foci were found in larger tumours (P = 0.031).ConclusionGreater extent of DCIS is associated with multifocal Mi.
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