• Eur. J. Clin. Invest. · Oct 2022

    Role of the Electrocardiogram in Differentiating Genetically Determined Dilated Cardiomyopathy from Athlete's Heart.

    • Denise Zaffalon, Efstathios Papatheodorou, Ahmed Merghani, Harshil Dhutia, Eleonora Moccia, Aneil Malhotra, Christopher J Miles, Virginia Attard, Tessa Homfray, Rajan Sharma, Marta Gigli, FerroMatteo DalMDCardiovascular Department, Azienda Sanitaria Giuliano-Isontina, University of Trieste, Trieste, Italy., Marco Merlo, Michael Papadakis, Gianfranco Sinagra, Sanjay Sharma, and Gherardo Finocchiaro.
    • Cardiovascular Department, Azienda Sanitaria Giuliano-Isontina, University of Trieste, Trieste, Italy.
    • Eur. J. Clin. Invest. 2022 Oct 1; 52 (10): e13837.

    BackgroundPhysiological cardiac remodelling in highly trained athletes may overlap with dilated cardiomyopathy (DCM).ObjectivesThe aim of this study was to investigate the role of the electrocardiogram (ECG) in differentiating between physiological and pathological remodelling.MethodsThe study population consisted of 30 patients with DCM who revealed a pathogenic variant at genetic testing and 30 elite athletes with significant cardiac remodelling defined by a left ventricular (LV) end-diastolic diameter >62 mm and/or LV ejection fraction between 45% and 50%.ResultsThe ECG was abnormal in 22 (73%) patients with DCM. The most common abnormalities were low voltages (n = 14, 47%), lateral T-wave inversion (TWI) (n = 6, 20%), ventricular ectopic beats (n = 5, 17%) and anterior TWI (n = 4, 13). Two athletes revealed an abnormal ECG: complete left bundle branch block (LBBB) in one case and atrial flutter in the other. The sensitivity, specificity and accuracy of the ECG in differentiating DCM from physiological adaptation to exercise in athletes was 73% (confidence interval [CI]: 54%-88%), 93% (CI: 78%-99%) and 0.83 (CI: 0.71-0.92) respectively.ConclusionsWhile the ECG is usually normal in athletes exhibiting significant LV dilatation and/or systolic dysfunction, this test is often abnormal in patients with DCM harbouring a pathogenic variant. Low voltages in the limb leads and lateral TWI are the most common abnormalities.© 2022 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

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