• Alessandra Grasso Giglio, Juliana de Brito Rangel, Cristiane Lemos Cardozo, Anke Bergmann, Gustavo Telles da Silva, and ThulerLuiz Claudio SantosLCS0000-0003-2550-6537Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil. lthuler@gmail.com.Brazilian National Cancer Institute (INCA), Instituto Nacional de Câncer, Coordenação de Pesquisa Clínica, Rua An.
• Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil.
• Eur Spine J. 2022 Nov 1; 31 (11): 313931453139-3145.

PurposeThe aim of this study was to determine the incidence and factors associated with the development of metastatic spinal cord compression (MSCC) after cervical cancer (CC).MethodsThis retrospective cohort of 3551 women with CC who underwent treatment at the Brazilian National Cancer Institute were included in the study. Clinical and sociodemographic variables were obtained from the Hospital Cancer Registry and from hospital records. A descriptive study of the population was carried out, using means and standard deviations or frequencies and percentages. The Kaplan-Meier curve was used to identify annual incidence rates. Associations between the independent variables and the outcome (MSCC) were evaluated by a univariate analysis, applying crude and adjusted odds ratios (aOR) assuming 95% confidence intervals.ResultsThe MSCC incidence was of 1.5% (n = 51), associated to advanced staging (aOR = 2.65, 95% CI: 1.45-4.85, p = 0.001) and initial treatment with concomitant chemotherapy and radiotherapy (aOR = 4.40, 95% CI: 1.74-11.13, p = 0.002).ConclusionsOur findings revealed the incidence and factors associated with MSCC, indicating a subset of patients who may be potential targets for the prevention and early treatment of this condition, indicating unprecedented and relevant data for the Brazilian epidemiological scenario due to the high CC incidence rates.© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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