• Critical care medicine · Feb 2009

    Randomized Controlled Trial Multicenter Study

    Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children.

    • Hülya Bayir, P David Adelson, Stephen R Wisniewski, Paul Shore, YiChen Lai, Danielle Brown, Keri L Janesko-Feldman, Valerian E Kagan, and Patrick M Kochanek.
    • Safar Center for Resuscitation Research, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
    • Crit. Care Med. 2009 Feb 1;37(2):689-95.

    ObjectiveOxidative stress contributes to secondary damage after traumatic brain injury (TBI). Hypothermia decreases endogenous antioxidant consumption and lipid peroxidation after experimental cerebral injury. Our objective was to determine the effect of therapeutic hypothermia on oxidative damage after severe TBI in infants and children randomized to moderate hypothermia vs. normothermia.DesignProspective randomized controlled study.SettingPediatric intensive care unit of Pittsburgh Children's Hospital.PatientsThe study included 28 patients.Measurements And Main ResultsWe compared the effects of hypothermia (32 degrees C-33 degrees C) vs. normothermia in patients treated in a single center involved in a multicentered randomized controlled trial of hypothermia in severe pediatric TBI (Glasgow Coma Scale score ConclusionTo our knowledge, this is the first study demonstrating that hypothermia attenuates oxidative stress after severe TBI in infants and children. Our data also support the concept that CSF represents a valuable tool for monitoring treatment effects on oxidative stress after TBI.

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