• Internal medicine · Jan 2022

    Case Reports

    Wild-type Transthyretin Amyloidosis with Diffuse Alveolar-septal Amyloidosis Diagnosed by a Transbronchial Lung Biopsy.

    • Masaki Ishida, Masamitsu Enomoto, Tae Hata, Tomoki Tanaka, Chikara Sakaguchi, Nobuyo Tamiya, Michiko Tsuchiya, and Yukio Nagasaka.
    • Pulmonary Medicine, University Hospital, Kyoto Prefectural University of Medicine, Japan.
    • Intern. Med. 2022 Jan 1; 61 (14): 2203-2207.

    AbstractA 69-year-old man visited our pulmonary medicine department for dyspnea. Chest computed tomography (CT) revealed ground-glass opacity bilaterally in the lungs. Upon performing a transbronchial lung biopsy (TBLB), organizing pneumonia was diagnosed. His electrocardiogram revealed low voltage, and the cardiac ultrasound revealed hypertrophy of the interventricular septum. The patient had bilateral carpal tunnel syndrome, and amyloidosis was suspected. Congo red stain was added to the lung biopsy specimen. Amyloid deposition of transthyretin (ATTR) was positive, mutations with amino acid changes were not observed in the TTR gene. Wild-type ATTR Amyloidosis (ATTRwt amyloidosis) was diagnosed using a TBLB. Chest CT after treatment with steroids revealed diffuse alveolar-septal amyloidosis.

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